Shimadzu IonFocus User manual

225-41675A

Jun. 2022

Atmospheric Pressure Ionization Interface

IonFocus™ Unit

Instruction Manual

Read this manual thoroughly before you use the product.

Keep this manual for future reference.

This page is intentionally left blank.

Read this Instruction Manual thoroughly before using

the product.

Thank you for purchasing this product.

This manual describes the installation, operation, usage cautions, accessories and options

for this product. Read this manual thoroughly before using the product and operate the

product in accordance with the instructions in this manual.

Keep this manual for future reference.

IMPORTANT

• If the user or usage location changes, ensure that this Instruction Manual is always

kept together with the product.

•If this manual or a product warning label is lost or damaged, immediately contact

your Shimadzu representative to request a replacement.

•To ensure safe operation, read all Safety Instructions before using the product.

•To ensure safe operation, contact your Shimadzu representative if product

installation, adjustment, re-installation (after the product is moved) or repairment

is required.

Notice

• Information in this manual is subject to change without notice and does not represent

a commitment on the part of the vendor.

• Any errors or omissions which may have occurred in this manual despite the utmost

care taken in its production will be corrected as soon as possible, although not

necessarily immediately after detection.

• All rights are reserved, including those to reproduce this manual or parts thereof in

any form without permission from Shimadzu Corporation.

• Note that Shimadzu will not be responsible for any damage resulting from operation

of the product in accordance with this Instruction Manual.

• Note that Shimadzu will not be responsible for the results of operating the product.

• Third-party trademarks and trade names may be used in this publication to refer to

either the entities or their products/services, whether or not they are used with

trademark symbol “TM” or “®”.

Original version is approved in English.

Introduction

IonFocus™ Unit i

Indications Used in This Manual

Precaution symbols are indicated using the following conventions:

Indication Meaning

Indicates a potentially hazardous situation which, if not

avoided, could result in serious injury or possibly death.

Indicates a potentially hazardous situation which, if not

avoided, may result in minor to moderate injury or equipment

damage.

Emphasizes additional information that is provided to ensure

the proper use of this product.

The following symbols are used in this manual:

Indication Meaning

Indicates an action that must not be performed.

Indicates an action that must be performed.

Indicates information provided to improve product performance.

Indicates the location of related reference information.

[ ]

Indicates buttons, menu items, settings, screens and windows,

icon names, and other text displayed on-screen.

　Example: Click [OK].

ii IonFocus™ Unit

Introduction

Safety Instructions

To ensure safe product operation, read these important safety instructions carefully

before use and follow all precaution instructions given in this section.

Also, refer to “Safety Instructions” of “LCMS Instruction Manual”.

nProduct Applications

Do NOT use the product for purposes other than those specified.

This product is an ionization unit for high performance liquid chromatograph

mass spectrometers.

Using it for an unspecified purpose may result in an accident.

This product (including accessories) is manufactured for measuring and

industrial purposes, and not suitable for household usage.

Safety regulations and standards

For notifications on installation and safety controls, follow the necessary

procedures in compliance with the laws and regulations applicable in the

country where the product is used.

nOperation

Provide electrostatic protection.

Take thorough measures to prevent

buildup of static electricity. Static electricity

could result in fire or explosion.

"Static Electricity Precautions"

P.vi

Wear protective goggles and protective

gloves.

Always wear protective gloves and

protective goggles when handling solvents

and samples. If solvent gets into the eyes,

blindness could result. Should solvent get

into the eyes, flush immediately with large

amounts of water and get medical

attention.

Always wear protective gloves when

handling any toxic or biologically infectious

samples.

IonFocus™ Unit iii

Safety Instructions

nInspection and Maintenance

Never remove the cover from the instrument.

This may cause injury or damage the instrument.

The cover does not need to be removed for routine maintenance or inspection.

Repairs inside the product must be performed by Shimadzu service personnel.

Contact your Shimadzu representative.

Do NOT disassemble or modify the product without permission.

Otherwise, you may receive an electric shock or a short circuit may occur.

Personal injury or product damage can also result.

Use the specified parts only.

Replacement parts must be of the specifications given in "Component Parts"

or "Maintenance Parts". Use of any other parts may result in malfunction in

the instrument.

Do NOT leave the instrument in wet condition nor use alcohol or thinner

solvents for cleaning the instrument.

Doing so could cause rust formation or discoloration.

To clean the instrument, wipe it with a soft cloth moistened with a small

amount of water or neutral detergent, and then wipe it with a soft dry cloth.

Do NOT dispose of waste liquids illegally.

Dispose of the waste liquid properly in accordance with the regulations and

instructions issued by your administrative department.

Turn the instrument's high voltage or power switch OFF before inspection,

maintenance or part replacement.

Otherwise, electric shock or short-circuit accidents could occur.

nHazards Involved in Repair, Disassembly, or Modification

Do NOT disassemble or modify the product without permission.

Otherwise, you may receive an electric shock or a short circuit may occur.

Personal injury or product damage can also result.

Contact your Shimadzu representative for repair inquiries.

Unauthorized repairs may cause a fire, electric shock, or injury.

iv IonFocus™ Unit

Introduction

nIn the Event of an Emergency

Take the following action in the event of an emergency, such as when a problem is

found with the high performance liquid chromatograph mass spectrometer to which this

unit is installed.

Perform a full inspection before using the product again, and if necessary, contact your

Shimadzu representative.

Emergency stop procedure

1Turn OFF the power switches at the mass spectrometer as well as the high

performance liquid chromatograph units.

2Turn OFF all the power switches at the peripheral equipment.

3Disconnect the rotary pump control cable that connects the rotary pump to the

mass spectrometer.

4Close the main cock of the gas tubing.

5Shut the power supply off.

• If the power cable is fastened to the distribution board, turn OFF the

switch at the distribution board.

• If the power cable is connected with a plug, unplug the power cable.

nDuring a Power Outage

If the 230 V AC power supply to the mass spectrometer is cut off and LabSolutions is

set to the automatic recovery mode, the vacuum system will automatically start after the

power is restored.

To set the automatic recovery mode, select [System Control] from the assistant

bar in the LabSolutions analysis window and check the [Vacuum Restart Mode]

box in the [System Control] window.

If automatic recovery is not set, start the instrument by referring to “Starting

the Instrument” of “LCMS Instruction Manual”.

IonFocus™ Unit v

Safety Instructions

Static Electricity Precautions

A liquid chromatograph (LC) uses flammable organic solvent(s) as the mobile phase. LC

systems are also often used where large amount of flammable substances are present.

Thus, an accident can produce large scale damage. Operators must be constantly on guard

against accidents involving fire or explosion.

The major cause of these accidents is static electricity. Devising preventative measures for

static can be difficult, because the symptoms before an accident vary and can be hard

to detect, since such accidents occur as a result of several simultaneous coincidences.

Recommended methods for preventing static electricity accidents are provided below.

Take thorough safety measures based on this information.

nTypical Cause of Static Electricity Accidents

Static electricity accidents are generally caused by this sequence of events:

Generation of static

electricity

When liquid is passed through thin tubing at high flow

rates, as in liquid chromatograph, the electrostatic charges

of the flowing matter generate static electricity.

↓

Accumulation of static

electricity

If electrostatically charged liquid is allowed to accumulate

in an electrically insulated container, the charge will

gradually increase, and can eventually reach several

thousand volts.

↓

Release of energy through

electrical discharge

If this happens and an electrical conductor is brought

within a certain distance of the container, an electrical

discharge will occur, releasing thermal energy.

↓

Ignition of flammable

substances

If any flammable gas of sufficient density is present in the

vicinity, such gas will ignite.

vi IonFocus™ Unit

Introduction

nPreventing Static Electricity Accidents

The best way to prevent static electricity accidents is simply to prevent the occurrence

and accumulation of electrostatic charges.

It is important to take multiple preventive measures simultaneously.

If large amounts of flammable solvents are collected in a large container,

implement preventive measures 1 - 5 below.

Preventive Measure 1

Use a conductive metal container for the waste liquid, and ground the container.

This will ensure that the electrical charges of the container and liquid pass to the ground.

• Grounding wire with clip Part No.: S228-21353-91

• 18 liter metal container Part No.: S038-00044

• 4 liter metal container Part No.: S038-00043-01

Be sure to ground the metal waste container properly.

If the grounding wire is not properly attached or connected to the ground,

static electricity can build up in the container.

Be sure to use a tester to verify that electricity is conducted to the ground.

Some metal containers have surfaces that are laminated or oxidized, and

therefore do not conduct electricity.

If the liquid to be drained into the waste container is virtually

non-conductive (10-10 S/m or less), it will be necessary to add properly

conductive, and therefore safe, liquid to the tank.

This conductive liquid may be added to the waste container beforehand.

IonFocus™ Unit vii

Safety Instructions

Preventive Measure 2

Restrict the openings at the waste container with caps or other protective covering to

prevent sparks generated outside the container from getting inside.

Caps for 18 liter or 4 liter containers (with three 3 mm diameter openings) Part No.:

S228-21354-91

Preventive Measure 3

Keep electrostatically charged objects, including the human body, away from the waste

container.

To prevent electrostatic charging of the human body, take the following precautions:

•Wear anti-static clothing and shoes.

• Ground the human body with anti-static wrist straps. (For safety, the wrist strap should

be connected to the ground using an intervening resistor of about 1 MW.)

• Spread anti-static matting or the like on the floor, to make the floor conductive.

Provide antistatic measures.

Persons who have not taken anti-static precautions should touch some

grounded metal object before coming near the waste container, in order to

drain static charges.

Preventive Measure 4

Use tubing with an inner diameter of at least 2 mm for drain lines with high flow rates.

Periodically check the tubing connections for air bubbles.

Air bubbles in liquid can multiply the electrostatic charge by a factor of 20,

30 or more.

viii IonFocus™ Unit

Introduction

Table of contents

Other Shimadzu Laboratory Equipment manuals

Shimadzu

Shimadzu AOC-20i User manual

Shimadzu

Shimadzu DGU-405 CL User manual

Shimadzu

Shimadzu LCMS-8050 User manual

Shimadzu

Shimadzu GC User manual

Shimadzu

Shimadzu GC-8A Series User manual

Shimadzu

Shimadzu GC17A User manual

Shimadzu

Shimadzu ICPE-9000 User manual

Shimadzu

Shimadzu FCV-S CL User manual

Shimadzu

Shimadzu LC-40D X3 CL User manual

Shimadzu

Shimadzu GCMS-QP2010 Series User manual

Shimadzu

Shimadzu GC-2014 User manual

Shimadzu

Shimadzu GCMS-QP2010 Series User manual

Shimadzu

Shimadzu iMLayer User manual

Shimadzu

Shimadzu Nexera CL Series Instruction Manual

Shimadzu

Shimadzu AP W-AD Series User manual

Shimadzu

Shimadzu Shim-pack GIST-HP Series User manual

Shimadzu

Shimadzu Nexera CL Series Parts list manual

Shimadzu

Shimadzu LC-10 User manual

Shimadzu

Shimadzu Shim-pack GIST Series User manual

Popular Laboratory Equipment manuals by other brands

Qiagen

Qiagen DML 3000 user manual

Queensgate

Queensgate NANOSCAN OP400 Quick start instructions

Conviron

Conviron GEN1000-GE Operator's manual

Parr Instrument

Parr Instrument 4560 Operating instructions manual

IKA

IKA IC control operating instructions

Integra

Integra DOSE IT operating instructions

Agilent Technologies

Agilent Technologies 5800 ICP-OES user guide

Endress+Hauser

Endress+Hauser Cleanfit CPA875 operating instructions

NI PXI-5422 CALIBRATION PROCEDURE

Collomix

Collomix Aqix operating instructions

SPEX SamplePrep

SPEX SamplePrep 6875 Freezer/Mill Series operating manual

Ocean Insight

Ocean Insight FLAME-NIR+ Installation and operation manual

Parker

Parker ALIGN-MG-NA Installation, operation and maintenance manual

BD 644787 user guide

DENTAURUM

DENTAURUM Compact Megaplus Instructions for use

Biuged Laboratory Instruments

Biuged Laboratory Instruments BGD 626 instruction manual

VWR

VWR SAS Super IAQ instruction manual

illumina

illumina MiSeqDx reference guide